Sunday, June 3, 2012

Study: Hormone pill slows prostate cancer's growth - seattlepi.com

CHICAGO (AP) ? A hormone-blocking pill approved last year for some men with advanced prostate cancer now also seems to help a wider group of men who were given it sooner in the course of treating their disease.

In a study of nearly 1,100 such men, Johnson & Johnson's Zytiga doubled the time patients lived without their cancer getting worse.

The drug also seems to be improving survival, but it will take longer follow-up to know for sure. Independent monitors stopped the study once it was clear the drug was helping and let men who had been getting dummy pills to switch to Zytiga. At that point ? after a median treatment time of two years ? 34 percent of men on dummy pills had died versus 27 percent of those taking Zytiga.

"Our hope is that this can become a new option" for up to 30,000 men each year in the United States, said study leader Dr. Charles Ryan of the University of California, San Francisco.

He gave results Saturday at a meeting in Chicago of the American Society of Clinical Oncology.

Prostate cancer is the most common cancer in American men. In the United States alone, more than 240,000 new cases and 28,000 deaths from the disease are expected this year. Many cases don't need treatment because the cancer grows so slowly it isn't a threat. For men who choose treatment when the disease is still confined to the prostate, surgery and radiation are common options.

Once it spreads, though, it often is treated with drugs that curb testosterone. They block about 90 percent of the hormone, "but that remaining 10 percent can still stimulate the cancer and cause death from the disease," Ryan said.

Zytiga blocks virtually all of it ? "it's really complete chemical castration," said another study leader, Duke University's Dr. Daniel George.

The drug won federal approval last year for men with advanced prostate cancer whose disease had worsened despite treatment with standard hormones and chemotherapy. The new study tested it earlier in the course of illness ? in men with advanced prostate cancer who have not yet received chemotherapy.

Researchers gave more than 1,000 patients in the U.S., Canada, Europe and Australia either Zytiga or dummy pills plus a steroid that also is widely used to treat such cases.

When the study was stopped, the median time until cancer worsened in the group getting dummy pills was about eight months. Those on Zytiga were faring much better, so doctors can only estimate the time it is taking for their cancers to worsen ? at least 16 months, Ryan said.

There were more cases of high blood pressure, fluid retention and heart problems among men on Zytiga. Like other hormone-blockers, it can cause hot flashes and sexual problems. And Zytiga is expensive ? $5,500 a month in the United States.

The study was sponsored by the drug's maker, Johnson & Johnson's Janssen division, and some study leaders have financial ties to the company. The company plans to seek approval later this year to sell the drug for men like those in the new study.

Michael Wells, 65, a retired construction worker from Oakville in California's Napa Valley, was diagnosed nearly 12 years ago with prostate cancer that had spread to his bones. Standard hormone and radiation treatments kept it in check for many years, but when it started growing, he enrolled in the study.

Zytiga gave him high blood pressure but other than that, "I have not noticed any difference taking the pills ? I've always had hot flashes" on prostate medicines, he said.

He has now been on Zytiga for nearly three years, and scans show his cancer is in check.

"It's worked for me, and it's still working," Wells said.

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

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Saturday, June 2, 2012

Target sells shirts to benefit gay rights

Two years after Target Corp. angered gay marriage supporters with a political donation that benefited a fiery gay marriage opponent seeking the governor's office, the retailer is now upsetting same-sex marriage opponents by selling T-shirts to raise money for a group working to defeat a gay marriage ban in Minnesota.

The Minneapolis-based retailer is taking heat in its home state, where voters will decide this November whether to put a gay marriage ban into the state constitution. One organizer of gay marriage opponents warned that their displeasure could spread to 32 other states where voters have banned gay marriage.

"Target is attacking traditional marriage, which is an incredibly misguided thing for them to have done," said Chuck Darrell, spokesman for Minnesota for Marriage, a group campaigning to pass the constitutional marriage amendment. "It's an insult to the overwhelming majority of their customers."

Target's move comes two years after it endured a backlash from gay rights supporters for giving $150,000 to a campaign group backing the conservative Republican candidate for Minnesota governor, Tom Emmer, who narrowly lost to Democrat Mark Dayton in a race that went to an automatic recount. The donation set off protests and calls for a boycott from a constituency that had seen Target as an ally.

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Supporters of gay marriage see Minnesota as having the potential to halt their long losing streak in statewide votes.

The T-shirt promotion will raise up to $120,000 for the Family Equality Council, a Washington-based group that is part of a Minnesota coalition pushing to defeat the constitutional amendment. The $12.99 shirts will be sold on Target's website through June, or while supplies last. They come in four designs, emblazoned with words such as "harmony" and "pride." Singer Gwen Stefani designed one shirt featuring a rainbow and a cloud that says, "LOVE IS LOVE."

Target hasn't taken a position on Minnesota's ballot question. Spokeswoman Molly Snyder said the T-shirt promotion was organized by a group of gay Target employees and their allies. She said it is Target's second promotion to benefit a specific group. The first, during last year's holiday season, raised money for St. Jude Children's Research Hospital through the sale of limited-edition plush dogs.

"Target is pleased to be able to bring our guests products they want while, in turn, helping support the LGBT community through the donation of 100 percent of the purchase price to the Family Equality Council," the company said in a statement noting its long-standing support of the gay community.

Another statement from the retailer notes "a broad range of strongly held views" on the marriage issue and urges employees to vote.

Family Equality Council director Jennifer Chrisler said the T-shirt proceeds will fund her group's work around the country, ranging from community building to political advocacy. She added that Target, a longtime sponsor of the Twin Cities gay pride festival, is now sponsoring Family Equality Council retreats for gay families in Massachusetts and California.

"I know and understand what a big reaction that donation had two years ago, and I think they have taken steps, serious steps, to show that they understood that reaction," Chrisler said. "But I really think this is an extension of the longtime partnership we have had and their commitment to family."

Minnesota for Marriage doesn't plan to organize action against Target because of its focus on the November vote, Darrell said. Instead, he is asking supporters of the constitutional amendment to counter the Target promotion by donating $12.99 on his group's website. He said donations are up since Target started selling the T-shirts.

Darrell also urged Target to get out of the marriage issue ? and stay out.

"Just get out of this debate and do what they're good at," Darrell said. "Get out of the business of trying to redefine marriage."

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Hospitality Careers | Indonesia 24 Jam

Hospitality CareersReviewed by Molinaallen on Jun 1.Rating:

In the tourism corporation there are many rewarding career prospects. The one person who oversees all of a propertys lodging operations is more often than not called a general manager. At larger hotels, one general manager supervises a staff of assistant managers of a few departments including office administration, housekeeping, purchasing, security, personnel, marketing and sales, maintenance, food and beverage, and guest recreation and relations. At a casino, the gaming operations might be a major division, and may even drive the business game plan for the entire brand name.

A successful lodging manager has to be a ?jack of all trades.? Lodging managers need wide-ranging responsibilities for the operation and profitability of the property. They may hire and train staff, and set schedules. Most importantly, a good general manager need to have experience and training within every facet of the resorts operations, from operating the coffee shop to knowing how to contract the linen service to running the web-based reservations system.

in many establishments, front office managers are accountable for the resorts guests and might oversee reservations and room assignments, and hire and train the resorts front desk staff. Convention services managers oversee meetings, conventions, and special events. marketing directors and public relations directors are accountable for meeting occupancy goals and coordinating the advertising and promotion of the property. Managers may work together with information technology specialists to ensure that the resorts pc systems, Internet, and communications networks are making value. Food and beverage managers supervise the hotels bar and catering activities.

Hows the Pay?

Earnings of lodging managers vary according to their location, responsibilities, and the segment of the travel corporation in which they work. According to a recent score by the U.S. Bureau of Labor Statistics Division of Occupational Employment Statistics, the median annual earnings of lodging managers is $42,320. The middle fifty percent earn between $31,870 and $58,380. The lowest ten percent earn less than $25,120 and the greatest ten percent earn greater than $82,510. For highly qualified individuals working within the upper echelons of the industry, the compensation can be significant.

Training and Advancement

While prior experience working inside the hospitality industry always helps, establishment trainees for larger hotels might need a bachelors or masters degree, preferably inside travel or hotel establishment. Most large, full-service chains more often than not look for candidates who have a bachelors degree within hotel, business, or tourism management. At smaller properties, particularly those together with fewer services, the pay might be lower but employers consider applicants together with an associate degree or certificate in hotel, restaurant, or tourism organization.

The Job Outlook

According to the U.S. Department of Labor Bureau of Labor Statistics (USBLS) Occupational Outlook Handbook, 2010-2011 Edition, employment growth can be around five percent a year and the employment market may be competitive. The government expects that vacancy seekers holding a college degree inside hotel or tourism organization can have better opportunities, especially at luxury and upscale hotels, cruise ships, and hotels. Shifts towards hotels along with limited personal service might result inside fewer opportunities for middle managers. fine consumer service skills and experience inside the hospitality industry, within addition to a school degree, are resources to any job seeker.

Train for a Rewarding Career in tourism

To find career studies opportunities, log onto a reputable college directory web site and request free information from schools and career colleges together with hospitality programs. Compare three or four programs, check out financial aid opportunities, and get a feel for their vacancy placement services. If you find a college that you like, schedule a campus visit or apply online.

If you are ready to move into an inspiring new career within hospitality, together with the right education you could have a bright destiny!

Hospitality Jobs / Hospitality Careers


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Ocean City Resort Uses Trademark Infringement Lawsuit to Bolster ...

Seacrets, an Ocean City, Maryland resort with a national reputation, recently succeeded in a federal trademark infringement lawsuit against a luxury hotel chain. The result, which included punitive damages and a permanent injunction against the competing hotel, is helping pave the way for Seacrets to move forward with its plans to expand nationally through franchising.

Franchising is a growth model that allows successful business owners to grant ?franchises? to independent business owners who then own and operate similar businesses under the franchisor?s tested business system. Central to any successful franchise system is a strong trademark ? the brand that represents the franchise in the public eye.

When a company seeks to expand nationally through franchising (or through any other method, for that matter), it needs to be confident that it will be able to use and protect its trademarks on a national scale. National exclusivity is obtained through trademark registration with the USPTO. However, even federal trademark registration won?t necessarily prevent startups and competitors from trying to use confusingly similar brands (case in point: the Seacrets trademark infringement lawsuit).

Thus, as this demonstrates, trademark registration with the USPTO is really only the start of the trademark protection process. Companies ? franchisors included ? need to proactively monitor and enforce their trademark rights in order to avoid market confusion, and in extreme cases even loss of exclusive rights altogether.

Getting back to the case, by taking care of this trademark infringement issue early, Seacrets not only took appropriate (and necessary) steps to protect its trademark, it also improved its position for transitioning into franchising.

This is because, among other things, franchisors are required to disclose pending litigation and threats to their trademarks in their Franchise Disclosure Documents. With a multi-million dollar investment on the line, as a potential franchisee would you rather see, ?We are aware of a third party?s use of a similar trademark that may negatively effect our rights in our principle trademark,? or ?We recently succeeded in obtaining a permanent injunction to enforce our exclusive trademark rights??

In addition, if a franchisor?s or other ?national? brand?s trademark rights are limited, it is going to run into practical issues at some point in its expansion. A ?prior rights? holder is likely going to be able to keep them out of certain geographical locations, and this means either (i) not going there at all, or (ii) developing an offshoot brand that is sufficiently dissimilar to avoid any trademark infringement implications. Of course, this means more trademark work anyway, not to mention the additional costs and administrative and regulatory issues that attend promoting multiple brands.

In conclusion, whether you are staring a new business, franchising, or exploring other expansion methods, securing exclusive trademark rights and monitoring and enforcing those trademark rights over the long haul should be top priorities. Only through consistent and proactive trademark protection can a business truly maintain control of its brands.

Jeff Fabian assists business owners in protecting their brands so that they can stay focused on running their businesses. Visit www.fabianip.com for more information, and follow Jeff on Twitter @FabianOnIP.

This article is provided for informational purposes only, and does not constitute legal advice.

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Friday, June 1, 2012

UK butterflies continue decline

The British butterfly population is continuing a marked downward trend.

This is according to a national survey which revealed that numbers of the insects fell by more than 20% between 2010 and 2011.

The results, announced by the charity Butterfly Conservation, appear to contrast with a recent study revealing a boom in numbers of rare UK species.

But while rare species may thrive in Britain's "pollinator hot spots", the more general outlook appears bleak.

Continue reading the main story

Top five butterflies

  • The meadow brown was the most widespread species, found in more than 80% of the areas surveyed in 2011
  • The small white was the second most commonly seen species; in just over 75% of the squares. This is fewer than 2010, however, when it was observed in 80% of survey areas
  • The green-veined white (above) increased in occurrence, appearing in 73% of sampled areas, compared to 69% in 2010
  • The large white was also found in 73% of survey squares, but its range contracted slightly between 2010 and 2011
  • The distribution of gatekeeper butterflies seemed to be stable. It was spotted across 70% of the countryside in 2010 and 2011

According to its co-ordinator, Dr Zoe Randle, the Wider Countryside Butterfly Survey (WCBS), gives a "scientifically robust" picture of the butterfly population throughout the country.

"It's carried out in randomly-generated one-kilometre squares," she told BBC Nature. "Because it's random, you can get a better idea of what's happening throughout the countryside."

In July and August 2011, more than 500 volunteers counted butterflies on these patches of countryside. Each person counted an average of 47 butterflies and saw seven different species.

This is a reduction of more than 20% in the number of butterflies per survey compared to 2010. It is also a 40% reduction compared with 2009, when each recorder saw an average of 80 butterflies and eight different species.

Butterfly Conservation has blamed the decline on "last year's record-breaking cold summer", but also said there was a long-term and "ongoing deterioration of suitable butterfly habitat across the countryside".

The once ubiquitous small tortoiseshell was one of the species badly-affected, with less than one seen per kilometre walked, on average.

Butterfly Conservation says that, less than a decade ago, this species was "likely to be seen in almost every garden and flowery place through the summer months".

Dr Randle explained that butterfly habitat throughout the UK was being lost and destroyed.

"The spread in modern agricultural practices, like use of pesticides and herbicides, makes it very difficult for butterflies," she explained.

"And it doesn't help that many people are ripping up lawns and putting out decking; butterflies can't live without a nectar source."

But the conservationist insisted it "wasn't all doom and gloom".

"Targeted agri-environment schemes can really benefit species," she said.

She also encouraged the public to plant "caterpillar food plants, and butterfly nectar plants, and added that it was a good idea to "leave a patch of your garden long with lots of flowers."

"We want to halt butterfly declines by 2020," Dr Randle said.

"And I think with the right targeted habitat management, we can do it."

Butterfly Conservation run this survey with the British Trust for Ornithology, and the UK Centre for Ecology and Hydrology.

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Getting carded: Banks stack fees on students

It took Mario Parker-Milligan less than a semester to decide that he was paying too many fees to Higher One, the company hired by his college to pay out students' financial aid on debit cards.

Four years after he opted out, his classmates still face more than a dozen fees ? for replacement cards, for using the cards as all-purpose debit cards, for using an ATM other than the two on-campus kiosks owned by Higher One.

"They sold it as a faster, cheaper way for the college to get students their money," said Parker-Milligan, 23, student body president at Lane Community College in Eugene, Ore. "It may be cheaper for the college, but it's not cheaper for the students."

As many as 900 colleges are pushing students into using payment cards that carry hefty costs, sometimes even to get to their financial aid money, according to a report to be released Wednesday by a public interest group.

Colleges and banks rake in millions from the fees, often through secretive deals and sometimes in apparent violation of federal law, according to the report, an early copy of which was obtained by The Associated Press.

More than two out of five U.S. higher-education students ? more than 9 million people ? attend schools that have deals with financial companies, says the report, written by the U.S. Public Interest Research Group Higher Education Fund.

The fees add to the mountain of debt many students already take on to get a diploma. U.S. student debt tops $1 trillion, according to the Consumer Financial Protection Bureau.

Student loans have surpassed credit cards as the biggest source of unsecured debt in America, according to the CFPB, which regulates cards and private student lenders.

Among the fees charged by Higher One, according to its website, is a $50 "lack of documentation fee" for students who fail to submit certain paperwork. The U.S. Department of Education called the charging of such fees "unallowable" in guidance to financial aid officers issued last month.

Higher One founder and Chief Operating Officer Miles Lasater said in an email that the company takes compliance with the government's rules "very seriously," and officially swears that to the government each year.

"We are committed to providing good value accounts that are designed for college students," he said, and students must review the company's fee list when they sign up for an account. He cited a study commissioned by Higher One that declared Higher One "a low-cost provider for this market." The same study found that the median fees charged to the 2 million students with Higher One accounts totaled $49 annually.

A plethora of fees
Among the fees charged to students who open Higher One accounts: $50 if an account is overdrawn for more than 45 days, $10 per month if the student stops using his account for six months, $29 to $38 for overdrawing an account with a recurring bill payment and 50 cents to use a PIN instead of a signature system at a retail store.

Higher One has agreements with 520 campuses that enroll more than 4.3 million students, about one-fifth of the students enrolled in college nationwide, according to public filings and the U.S. PIRG report. Wells Fargo and US Bank combined have deals with schools that enroll 3.7 million, the report says.

Lane Community College's president, Mary Spilde, said in an interview that the real problem is a "lack of adequate public funding," which forces students to seek financial aid and colleges to find ways to cut costs.

"Many institutions are looking at ways to streamline and to do things that we're good at, which is education and learning, and not banking," Spilde said.

Programs like Higher One's shift the cost of handing out financial aid money from universities, which no longer have to print and mail checks, to fee-paying students, said Rich Williams, the report's lead author.

"For decades, student aid was distributed without fees," Williams said. "Now bank middlemen are making out like bandits using campus cards to siphon off millions of student aid dollars."

Students can opt out of the programs and choose direct deposit or paper checks to receive their college aid, but relatively few do. The cards and accounts are marketed aggressively using college letterhead and websites carrying the endorsement of colleges. Higher One also warns students that it will take extra days if they choose direct deposit or a paper check.

In the end, students feel locked into accounts before they have a chance to shop for a better deal, Parker-Milligan said.

He said that's especially tough for poor students who rely on food stamps and other social services. Those students budget down to the penny, and don't plan on paying a fee when Higher One's ATM runs out of cash, he said.

Offerings by financial companies vary by campus. Some issue checking accounts with debit cards. Others offer prepaid debit cards, which are similar to bank debit cards but can carry higher fees and offer fewer consumer protections.

Often, students' campus ID cards double as payment cards. At the University of Minnesota, TCF Bank issues cards that serve as school IDs, ATM and debit cards, library cards, security cards, health care cards, phone cards, and stored-value cards for vending machines, the report said. TCF also has branches on campus and 25-year naming rights to the football stadium. Its cards charge similar fees, the report says.

Visibility on campus
Having such visibility on campus is a big benefit for banks seeking exclusive access to an untapped group of potential customers. Many banks are willing to pay universities for the privilege.

Under its contract with Huntington Bank, Ohio State University will receive $25 million over 15 years, plus a sweetener of $100 million in loans and investments for the neighborhoods around campus, the report said. Florida State receives a portion of every ATM fee paid by a student, it says.

It's difficult to get a full picture of how much money the schools are getting because most of them refuse to release their contracts with banks. Only a handful were available to the authors of the report.

Ohio State and Florida State did not immediately respond to requests for comment. The National Association of College and University Business Officers, a trade group involved in the issue, did not respond to multiple requests for comment.

Lane Community College receives no payments under its contract with Higher One, Spilde said. Lasiter said Higher One does not "offer revenue sharing" to colleges that it partners with. However, Higher One does pay some universities under existing contracts, according to the U.S. PIRG report.

Campus card deals have become more popular in part because of recent legal changes that cut into the profits banks can generate from students.

A 2009 law banned credit cards given to students who had no way of repaying. It forced colleges to disclose deals with credit card companies and stopped some forms of marketing, such as offering students free gifts in exchange for obtaining a credit card.

Until recently, banks also made a lot more money from student loans. They extended federal aid to students, and also offered confusingly similar, higher-cost private loans alongside the government programs. Congress cut them out of the equation in 2010.

Neither change affected debit cards. As the recession forced states to slash higher education budgets, companies such as Higher One, Wells Fargo and US Bank approached colleges with an attractive proposition: The companies would assume the cost and hassle of handing out student aid funds, often paying for the privilege.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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